Colivelin TFA (867021-83-8 free base)
CAS No.
Colivelin TFA (867021-83-8 free base) ( )
Catalog No. M29977 CAS No.
Colivelin (TFA) is a hybrid peptide composed of ADNF and AGA-(C8R)HNG17, a potent Humanin (HN) derivative.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
Biological Information
-
Product NameColivelin TFA (867021-83-8 free base)
-
NoteResearch use only, not for human use.
-
Brief DescriptionColivelin (TFA) is a hybrid peptide composed of ADNF and AGA-(C8R)HNG17, a potent Humanin (HN) derivative.
-
DescriptionColivelin (TFA) is a hybrid peptide composed of ADNF and AGA-(C8R)HNG17, a potent Humanin (HN) derivative.(In Vitro):Colivelin (TFA) is a hybrid peptide composed of ADNF and AGA-(C8R)HNG17, a potent Humanin (HN) derivative. Humanin (HN) and its derivatives, such as Colivelin (TFA), suppress neuronal death induced by insults related to Alzheimer's disease (AD) by activating STAT3. Colivelin (TFA) completely suppresses death induced by overexpressed FAD-causative genes and A 1-43 at a concentration of 100 fM, whereas AGA-(C8R)HNG17 does so at a concentration of 10 pM.(In Vivo):Humanin (HN) and its derivatives, such as Colivelin (TFA) also ameliorate functional memory impairment of mice induced by anticholinergic drugs or soluble toxic amyloid-β (Aβ). Intracerebroventricular administration of Colivelin (TFA) not only completely suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Aβ25-35 or Aβ1-42, but also it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Aβ1-42.
-
Synonyms
-
PathwayOthers
-
TargetOther Targets
-
RecptorSTAT3
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number--
-
Formula Weight2759.1
-
Molecular FormulaC119H206N32O35.C2HF3O2
-
Purity>98% (HPLC)
-
SolubilityH2O : 25 mg/mL (9.06 mM; Need ultrasonic)
-
SMILES——
-
Chemical Name
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
Yamada M, et al. Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology. 2008 Jul;33(8):2020-32.
molnova catalog
related products
-
3-hydroxy-phthalican...
3-Hydroxyphthalic anhydride is used to synthesize 3-hydroxyphthalic anhydride modified human serum albumin.
-
Lapathoside A
Lapathoside A and vanicoside B, inhibited the promotion stages on two-stage carcinogenesis induced by TPA.
-
WL 47 - dimer
High affinity caveolin-1 (CAV1) ligand (Kd = 23 nM); disrupts caveolin-1 oligomers. Exhibits selectivity for CAV1 over BSA, casein and HEWL.